Table 2

Parameters for final model (Model 2 [E5≠ E10]) with all covariates
Variable Units Mean value, θ± SE Intersubject variability, η± SE
Placebo growth rate, r 10-3 cm/day 46.0 ± 5.7 3.5 ± 2.1
Drug effect of 10 mg, E10 10-3/day 3.9 ± 0.5 0.3 ± 0.2
Drug effect of 5 mg, E5 10-3/day 2.3 ± 0.5 0.2 ± 0.2
Multiplicative effect of baseline SLD on placebo growth rate, θ1 0.4 ± 0.2 NA
Multiplicative effect of baseline SLD on drug effect, θ2 −0.7 ± 0.2 NA
Residual error, σε cm 1.1 NA

NA, not applicable; SE, standard error; SLD, sum of the longest tumor diameters.

Intersubject variability (η) denotes the standard deviation of the parameter distributions.

Stein et al.

Stein et al. BMC Cancer 2012 12:311   doi:10.1186/1471-2407-12-311

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