Additional file 7 Figure S3.
The landscape of CNAs in RCC does not correlate with novel molecular subgroups. (A) Regional genomic CNAs in RCC shown as percentage of analyzed cases (genomic gains: yellow, up; losses: blue, down). Top: depiction of the overall CNAs in the 45 study cases; Down: published chromosomal and array CGH RCC data accessible through the Progenetix database (568 cases). Copy number variants (CNVs) were not filtered from the study case data besides application of a 100 kb size limit. Note the similar profiles. (B) Case specific regional copy number imbalances in 36 RCC study cases with regional genomic gain or loss status matched to 811 cytogenetic regions. The genomic profiles are randomly arranged within their subtypes. White areas indicate concurrent gain and loss in this cytoband. Note the appearance of known subtype-specific genomic alterations (3p deletions, 5q gains identifying clear cell RCC – asterisk and arrow/left side; gains of chromosomes 7, 17 and 20 identifying papillary RCC - arrows right side).
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Beleut et al. BMC Cancer 2012 12:310 doi:10.1186/1471-2407-12-310