Table 2

Severe toxicity per treatment group (as treated population)*
Group A Group B
(XELIRI-Bev) (FOLFIRI-Bev)
N = 133 N = 132
Grade III Grade IV Grade III Grade IV
N % N % N % N %
Anemia 1 1 1 1
Leucopenia 8 6 1 1 5 4
Neutropenia 11 8 6 5 25 19 4 3
Febrile Neutropenia 2 2 2 2 2 2
Thrombocytopenia 1 1
Infection 2 2
Fever 2 2
Fatigue 3 2 3 2
Anorexia 2 2
Nausea 1 1
Vomiting1 7 5
Mucositis 1 1 2 2
Diarrhea 24 18 1 1 14 11
Other gastrointestinal 1 1
Cholinergic syndrome 1 1
Hiccups 1 1
Voice changes 1 1
Transaminasemia 3 2 1 1
Hand–foot syndrome 1 1 1 1
Metabolic 3 2 1 1 4 3 2 2
Allergic reaction 1 1
Electrolyte disturbances 7 5 7 5 1 1
Hypertension 6 5 5 4
Thrombosis 4 3 5 4 2 2
Pulmonary embolism 1 1
Syncope 1 1 5 4
Cardiac 1 1 1 1 1 1 2 2
Hemorrhage 1 1

*Pearson chi-square and Fisher’s exact tests were applied to compare severe toxicities (all p values above 0.05, except for vomiting).

1Fisher’s exact test, p = 0.014.

Pectasides et al.

Pectasides et al. BMC Cancer 2012 12:271   doi:10.1186/1471-2407-12-271

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