Assessment of NSG mouse derived tumors. Tumors established in NSG mice after intravenous injection of Z138 MCL cells were analyzed for specific SOX11 expression. (A) IHC-P staining showed a human B cell phenotype (CD20) and confirmed nuclear staining of SOX11. (B) Flow cytometry analysis separated SOX11 positive and negative cells, derived from two separate tumors established in NSG through injection of knocked (SOX11-) and unknocked (SOX11+) Z138 cells.
Nordström et al. BMC Cancer 2012 12:269 doi:10.1186/1471-2407-12-269