Functional form of the association of cholesterol with the relative hazard of Gleason 8 to 10 prostate cancers estimated in a Cox proportional hazards model using age as the time axis. The function was fitted using restricted cubic splines with three knots (X). The function was standardized such that the HR was 1 at the mean cholesterol level of the lowest quintile. Dotted lines indicate the 95% confidence intervals.
Shafique et al. BMC Cancer 2012 12:25 doi:10.1186/1471-2407-12-25