Table 1

Chromosome imbalance regions in lung cancer (alteration frequency > 50%)
Chromosome Cytobanda Start siteb End siteb Size (Mb)c BAC number Alteration frequency (n=40) Gene numberd
A. Asian
3 p13-14.1* 64934270 73536726 8.60 74 Gain: 73% 23
6 p22.1* 26562439 28452189 1.89 60 Gain: 70% 31
9 q21.13* 73445866 76242707 2.80 29 Gain: 70% 8
10 q21.3 69354590 71006065 1.65 15 Gain: 55% 23
10 q24.1 95664566 99431796 3.77 37 Gain: 58% 44
12 p13.31-13.32 2363194 8268165 5.90 44 Gain: 60% 58
13 q14.1-14.2* 42340030 47097431 4.76 38 Gain: 80% 22
17 p13.3* 373082 2754327 2.38 20 Gain: 60% 37
2 p23.2-23.3 25035233 33995335 8.96 75 Loss: 63% 83
2 p24.1 21212355 23783250 2.57 18 Loss: 58% 1
2 q35 215083214 215870969 0.79 9 Loss: 58% 5
3 p21.3-22.3* 33902686 44181635 10.28 82 Loss: 65% 90
4 p15.2-15.31 22255381 24549727 2.29 24 Loss: 60% 5
6 p22.2 23982002 25939112 1.96 68 Loss: 80% 16
12 q15 67646357 69188647 1.54 11 Loss: 55% 11
13 q13.3* 35856763 39003721 3.15 27 Loss: 65% 18
X p22.31 5701499 5872842 0.17 2 Loss: 50% 1
Overall 476
B. Caucasian
2 p24.1-24.3 12723105 21045423 8.32 58 Gain: 55% 21
2 q25.1 11704089 12544967 0.84 7 Gain: 50% 2
3 p12.3-13* 67690502 79574641 11.88 96 Gain: 70% 22
3 p14.1-14.3* 56804094 67550231 10.75 65 Gain: 50% 26
3 p21.31-22.1 42559388 46459596 3.90 33 Gain: 60% 57
3 p25.3-26.3 1711179 9591700 7.88 72 Gain: 55% 20
6 p22.1-22.3* 20951128 28567815 7.62 132 Gain: 60% 97
9 q21.13* 75834015 76513536 0.68 6 Gain: 70% 5
13 q14.1-14.2* 40944092 47097431 6.15 47 Gain: 80% 24
17 p13.2-13.3* 481074 4001084 3.52 13 Gain: 70% 35
X p22.11-22.2 16180300 22691476 6.51 49 Gain: 60% 26
2 p22.3 32854381 33890229 1.04 6 Loss: 50% 3
2 p24.3-25.1 31026798 31813698 0.79 6 Loss: 50% 3
3 p11.1-12.1 84572959 90247330 5.67 46 Loss: 70% 9
3 p22.2-22.3* 32980614 36795763 3.82 13 Loss: 75% 14
3 p23 31259835 32891762 1.63 13 Loss: 60% 10
6 p21.2-22.1 29049491 39602226 10.55 86 Loss: 70% 27
10 p23.1-23.2 82106537 89500949 7.39 79 Loss: 60% 36
12 p12.31 8090287 9190860 1.10 7 Loss: 50% 18
13 q13.3* 35856763 36315193 0.46 5 Loss: 80% 4
Overall 459

a The common alteration regions in both Asian and Caucasian are marked with asterisk (*).

b The information of cytoband start site and end site nucleotide sequences were from UCSC database (http://genome.ucsc.edu/, build 36 - hg18).

c The sizes of cytoband were calculated from the start site to the end site nucleotide sequences.

d The gene number of candidate genes was estimated by “NimbleGen: Transcription_Start_Sites.gff” annotation file (Roche, Palo Alto, CA). The annotation file indicates all transcription initiation sites for build hg18 as reported in the UCSC Genome browser.

Lo et al.

Lo et al. BMC Cancer 2012 12:235   doi:10.1186/1471-2407-12-235

Open Data