Table 1

Top 20 up and downregulated genes in p80HT B cells
Gene RefSeq Fold Pvalue Gene ontology/biological function
Penk NM_001002927 5.77 0.00098 Neuropeptide signaling pathway
Hbb-b1 NM_008220 4.87 0.00662 Positive regulation of cell proliferation
IL-15 NM_008357 4.57 0.00112 Lymph node development
Lphn2 NM_001081298 4.06 0.00248 G-protein coupled receptor protein signaling pathway
IL-10 NM_010548 4.02 0.00715 Immune response/regulation of gene expression
Hba-a2 NM_001083955 3.95 0.00213 Oxygen transport
Hba-a1 NM_008218 3.74 0.00248 Oxygen transport
B4galt6 NM_019737 3.72 0.00044 Galactosyltransferase activity
Ehf NM_007914 3.67 0.00004 Positive regulation of transcription, DNA-dependent
CD80 NM_009855 3.65 0.00156 Positive regulation of peptidyl-tyrosine phosphorylation
Dmxl2 NM_172771 3.61 0.00185 Rab GTPase binding
Ryk NM_013649 3.24 0.00229 Wnt receptor signaling pathway
Pmepa1 NM_022995 3.21 0.00149 Protein binding
Mllt4 NM_010806 2.95 0.00013 Cell adhesion/signal transduction
Csf2rb NM_007780 2.88 0.00081 Cytokine-mediated signaling pathway
Ikzf2 NM_011770 2.78 0.00628 Regulation of transcription
Nt5e NM_011851 2.77 0.00001 AMP catabolic process
Plscr1 NM_011636 2.75 0.00348 Response to virus
Tnfsf8 NM_009403 2.68 0.00839 Immune response
Ccnd2 NM_009829 2.58 0.00868 Regulation of cell cycle
Vpreb3 NM_009514 -3.95 0.00584 Pre-B cell receptor (BCR) signals
Hes1 NM_008235 -3.78 0.00235 Negative regulation of transcription
Rapgef4 NM_019688 -3.58 0.00435 Regulation of protein amino acid phosphorylation
Zfp608 NM_175751 -3.55 0.00982 Zinc ion binding
Cecr2 NM_001128151 -3.19 0.00535 Apoptosis
Tmem108 NM_178638 -3.02 0.00574 Tramsmembrane protein
CD36 NM_001159557 -2.79 0.00040 Positive regulation of cell-matrix adhesion
D8Ertd82e NM_172911 -2.55 0.00168 Protein amino acid phosphorylation
Treml2 NM_001033405 -2.47 0.00796 T cell activation
Slc6a16 XM_914689 -2.41 0.00426 Solute carrier
Hist3h2a NM_178218 -2.40 0.00475 Nucleosome assembly
Satb1 NM_009122 -2.36 0.00289 Negative regulation of transcription
Rftn2 NM_028713 -2.33 0.00548 Raftlin Family
Gad1 NM_008077 -2.32 0.00184 Carboxylic acid metabolic process
Gdf11 NM_010272 -2.30 0.00225 Negative regulation of cell proliferation
Itgb3 NM_016780 -2.16 0.00482 Integrin-mediated signaling pathway
Acsf2 NM_153807 -2.13 0.00050 Fatty acid metabolic process
Zfp69 NM_001005788 -2.05 0.00718 Regulation of transcription, DNA-dependent
Pip5k1b NM_008846 -2.05 0.00710 Phosphatidylinositol metabolic process
Smad7 NM_001042660 -2.03 0.00463 Negative regulation of transcription

McCarthy et al.

McCarthy et al. BMC Cancer 2012 12:203   doi:10.1186/1471-2407-12-203

Open Data