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Plant HDAC inhibitor chrysin arrest cell growth and induce p21WAF1 by altering chromatin of STAT response element in A375 cells

Manika Pal-Bhadra1*, M Janaki Ramaiah12, T Lakshminarayan Reddy1, Anita Krishnan12, SNCVL Pushpavalli1, K Suresh Babu3, Ashok K Tiwari4, J Madhusudana Rao3, Jhillu S Yadav1 and Utpal Bhadra2*

Author Affiliations

1 Department of Chemical Biology, Indian Institute of Chemical Technology, Uppal Road, Hyderabad, 500007, India

2 Functional Genomics and Gene silencing Group, Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, 500007, India

3 Department of Natural Product, Indian Institute of Chemical Technology, Uppal Road, Hyderabad, 500007, India

4 Department of Pharmacology, Indian Institute of Chemical Technology, Uppal Road, Hyderabad, 500007, India

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BMC Cancer 2012, 12:180  doi:10.1186/1471-2407-12-180

Published: 16 May 2012

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