Profile changes of in vitro KPL-4 cells compared to circulating KPL-4 cells out of tumour bearing animals. Samples were analysed using RT2 Profiler PCR Array System focusing on EMT specific genes. Data analyses shows that COL5A2, EGFR, MSN, PDGFRB and Twist were upregulated on CTCs whereas downregulation of CK-19 and SPP1 could be observed (n = 5).
Gorges et al. BMC Cancer 2012 12:178 doi:10.1186/1471-2407-12-178