Table 3

Univariate analysis of prognostic factors in term of overall survival and HCC-specific overall survival
Characteristic HCC-specific overall survival rate (%) Overall survival rate (%)
3y 5y P value 3y 5y P value
Gender 0.901 0.815
  Female (n = 7) 45.5 38.4 85.7 64.3
  Male (n = 61) 51.4 34.3 58.0 50.4
Age (years)* 0.441 0.612
  < 58 (n = 33) 52.3 47.1 62.7 62.7
  ≥58 (n = 35) 40.5 27.1 59.8 41.7
HBsAg status 0.148 0.909
  Negative (n = 23) 40.0 28.6 56.0 49.1
  Positive (n = 45) 50.8 36.2 62.4 51.8
AFP (ug/l) 0.034 0.252
  ≤ 25 (n = 30) 62.9 48.4 68.9 68.9
  >25 (n = 38) 32.6 27.2 54.9 39.6
GGT level (u/l) 0.040 0.073
  ≤ 50 (n = 23) 71.8 71.8 76.5 76.5
  > 50 (n = 45) 35.9 29.4 52.9 43.8
Cirrhosis .255 0.078
  No (n = 17) 65.8 65.8 85.6 66.3
  Yes (n = 51) 40.9 29.5 52.9 46.8
Child-Pugh classification 0.334 0.083
  A (n = 49) 50.8 39.7 64.6 59.8
  B (n = 19) 36.4 27.3 48.2 32.8
Tumor size (cm) 0.865 0.537
  ≤5 (n = 28) 49.0 42.0 62.8 47.3
  >5 (n = 40) 44.6 31.5 59.7 48.0
Multiple tumors 0.001 0.221
  No (n = 49) 58.0 48.1 65.3 57.7
  Yes (n = 19) 11.1 11.1 62.1 41.4
Vascular invasion 0.001 0.977
  No (n = 58) 51.7 40.2 60.2 52.3
  Yes (n = 10) 0 0 66.8 53.4
TNM stage <0.001 0.698
  I (n = 43) 58.4 50.0 61.4 54.0
  II/III (n = 25) 17.1 0 60.1 47.7
Time of appearance 0.360 0.008
  Synchronous (n = 22) 34.5 23.0 25.7 25.7
  Metachronous (n = 46) 50.3 40.3 72.8 61.3
Treatment for HCC <0.001 0.160
  Resection (n = 35) 71.9 52.0 64.9 64.9
  Ablation (n = 8) 50.8 50.8 66.7 50.0
  TACE (n = 14) 0 0 50.0 37.6
  Supportive (n = 11) 0 0 40.0 26.7
Treatment for EHPM 0.067 <0.001
  Curative (n = 54) 47.3 33.2 72.4 63.4
  Palliative (n = 8) 19.2 19.2 35.7 17.9
  Supportive (n = 6) 11.7 11.7 0 0

HCC: hepatocellular carcinoma, HBsAg: hepatitis B surface antigen, AFP: α-fetoprotein, GGT: gamma-glutamyltransferase, TACE: transarterial chemoembolization, EHPM: extrahepatic primary malignancy.

* Patients were divided according to the median age.

Resection vs. Ablation P = 0.346; Ablation vs. TACE P < 0.001; TACE vs. Supportive P = 0.413.

Radical vs. Palliative P < 0.001; Palliative vs. Supportive P = 0.122.

Zeng et al.

Zeng et al. BMC Cancer 2012 12:148   doi:10.1186/1471-2407-12-148

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