Open Access Research article

Relevance of activated leukocyte cell adhesion molecule (ALCAM) in tumor tissue and sera of cervical cancer patients

Maike Ihnen1, Kerstin Kress1, Jan Felix Kersten2, Ergin Kilic3, Matthias Choschzick3, Hilke Zander4, Volkmar Müller1, Sven Mahner1, Fritz Jänicke1, Linn Woelber1 and Karin Milde-Langosch1*

Author Affiliations

1 Department of Gynecology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany

2 Department of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany

3 Institute for Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany

4 Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany

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BMC Cancer 2012, 12:140  doi:10.1186/1471-2407-12-140

Published: 4 April 2012

Additional files

Additional file 1:

Figure S1: Cytoplasmic and membraneous ALCAM reactivity. Examples of ALCAM immunostaining in three cervical carcinomas showing concomitant cytoplasmic and membraneous ALCAM reactivity in tumor cells.

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Additional file 2:

Table S1: Multivariate analysis in the total cohort. The table shows a Cox regression analysis for disease-free survival (DFS) and cancer-specific survival (CSS) in the total cohort including FIGOn stage, nodal involvement, grading, histological type, and ALCAM immunoreactivity.

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Additional file 3:

Table S2: Distribution of clinical and histological prognostic factors among subcohorts of cervical cancer patients. After stratification according to the applied therapy, a multivariate analysis could not be performed due to the small subgroup sizes. We therefore analysed the distribution of the clinicopathological prognostic markers in each therapy group and in the subgroups showing low and high ALCAM expression. By this approach we could demonstrate that histopathological and clinical tumor characteristics were similarly distributed between all groups, indicating that the predictive effect of ALCAM expression in the chemoradiation group was independent.

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