Table 3

KI benefit response after the second treatment cycle (worst case scenario)

KI benefit response a All patients (N = 521) n (%) of patients [95% CI]


Responders overall

302 (58.0) [53.6; 62.2]


0% improvement of KI, but maintained ≥ 80%

151 (29.0)


10% improvement of KI

97 (18.6)


20% improvement of KI

7 ( 1.3)


30% improvement of KI

2 ( 0.4)


Worsening of KI, but still maintained ≥ 80%

45 ( 8.6)


Non-responders, overall

219 (42.0) [37.8; 46.4]


0% worsening of KI, but maintained < 80%

67 (12.9)


Deterioration of KI, developed KI < 80%

102 (19.6)


Missing data b

50 ( 9.6)


CI confidence interval, KI Karnofsky Index, N = total number of patients, n = number of patients

a) Defined as improvement in KI of at least 10% (absolute) or maintenance/achievement of an absolute KI of at least 80%

b) Patients who discontinued prior to the end of the second treatment cycle or who had missing KI data were considered as non-responders (worst case scenario)

Schuette et al. BMC Cancer 2012 12:14   doi:10.1186/1471-2407-12-14

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