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Open Access Commentary

The clinical significance of tumor infiltrating lymphoctyes in breast cancer: does subtype matter?

Jonathan Krell*, Adam E Frampton and Justin Stebbing

Author Affiliations

Department of Surgery and Cancer, Imperial College, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK

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BMC Cancer 2012, 12:135  doi:10.1186/1471-2407-12-135

Published: 3 April 2012


Tumor infiltrating lymphocytes (TILs) are commonly detected in breast tumors but their bearing on disease outcome is uncertain. The importance of TILs appears to be subtype-specific and varies depending on the histologic characteristics of the tumor. As our understanding of tumorigenesis is increasing the relevance of immunobiology will become apparent.

Tumor infiltrating lymphocytes; Cancer; Immunobiology