Open Access Highly Accessed Research article

Nuclear expression of Rac1 in cervical premalignant lesions and cervical cancer cells

Miguel A Mendoza-Catalán1, Gema R Cristóbal-Mondragón1, Jesús Adame-Gómez1, Heidi N del Valle-Flores1, José Fco Coppe2, Laura Sierra-López2, Mirna A Romero-Hernández3, Luz del Carmen Alarcón-Romero3, Berenice Illades-Aguiar4 and Eduardo Castañeda-Saucedo15*

Author Affiliations

1 Laboratorio de Biología Celular del Cáncer, UACQB, Universidad Autónoma de Guerrero, Guerrero, Mexico

2 Unidad de Patología. Hospital Vicente Guerrero, IMSS, Acapulco, Guerrero, Mexico

3 Laboratorio de Citopatología, UACQB, Guerrero, Mexico

4 Laboratorio de Biomedicina Molecular, UACQB, Guerrero, Mexico

5 Laboratorio de Biología Celular del Cáncer. Edificio "F" segundo piso, UACQB, Universidad Autónoma de Guerrero. Ciudad Universitaria, Av. Lázaro Cárdenas s/n, Chilpancingo, Guerrero CP. 39090, Mexico

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BMC Cancer 2012, 12:116  doi:10.1186/1471-2407-12-116

Published: 23 March 2012

Additional files

Additional file 1:

Figure S1. HR-HPV detection by ISH. Representative images of (a) L-SIL sample in which HPV-probe set was excluded (negative control); (b-d) HR-HPV positive H-SIL showing strong nuclear staining. (a-c) 40×, (d) 100 ×.

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Additional file 2:

Figure S2. Establishment of the criteria for interpretation of IHC results. To analyze the differences in the intensity in immunoreactivity of the five proteins, we defined four categories based on signal intensity: a) negative, b) low, c) moderate and d) strong.

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Additional file 3:

Table S1. Characteristics of the study population.

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