miR-135a increased breast cancer cells migration and invasion properties. (A) Migration and invasion after transfection of BT549 cells with a miR-135a inhibitor or no inhibitor (N.C.). Images of invasive BT549 cells (left panel). (B) Migration and invasion assays after transfection of SKBr3 cells with pSilencer-miR-135a (pS-135a) or pSilencer4.1CMV-negative (pS-N). Images of invasive SKBr3 cells (top panel). (C) Migration and invasion assays after transfection of MDA-MB-231 cells with pS-135a or pS-N. Images of invasive MDA-MB-231 cells (top panel). (D) Cell proliferation of MDA-MB-231 cells transfected with pS-135a or pS-N, and BT549 cells transfected with the miR-135a inhibitor or negative control (N.C). n = 3, *, p < 0.05, significantly decreased migration or invasion.
Chen et al. BMC Cancer 2012 12:111 doi:10.1186/1471-2407-12-111