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Open Access Research article

Interleukin-10-819 promoter polymorphism in association with gastric cancer risk

Huiping Xue12*, Bing Lin3, Jianfu An4, Yuyuan Zhu5 and Gang Huang5*

Author Affiliations

1 Division of Gastroenterology and Hepatology, Shanghai Jiaotong University School of Medicine Renji Hospital, Shanghai Institution of Digestive Disease, Shanghai, People's Republic of China

2 Key Laboratory of Gastroenterology & Hepatology, Ministry of Health(Shanghai Jiaotong University), Shanghai, People's Republic of China

3 Division of Nutrition, Zhongshan Hospital, Fudan University School of Medicine, Shanghai, People's Republic of China

4 Division of Bioinformatics, Shanghai Jiaotong University School of Medicine,, Shanghai, People's Republic of China

5 Department of Nuclear Medicine, Shanghai Jiaotong University School of Medicine Renji Hospital, Shanghai, People's Republic of China

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BMC Cancer 2012, 12:102  doi:10.1186/1471-2407-12-102

Published: 21 March 2012

Abstract

Background

Potential functional allele T/C single nucleotide polymorphism (SNP) of Interleukin 10 (IL-10) promoter -819 (rs1800871) has been implicated in gastric cancer risk. We aimed to explore the role of T/C SNP of IL-10 -819 in the susceptibility to gastric cancer through a systematic review and meta-analysis.

Methods

Each initially included article was scored for quality appraisal. Desirable data were extracted and registered into databases. 11 studies were ultimately eligible for the meta-analysis of IL-10 -819 T/C SNP. We adopted the most probably appropriate genetic model (recessive model). Potential sources of heterogeneity were sought out via subgroup and sensitivity analyses, and publication biases were estimated.

Results

IL-10 -819 TT genotype is associated with the overall reduced gastric cancer risk among Asians and even apparently observed among high quality subgroup Asians. IL-10-819 TT genotype is not statistically associated with the overall reduced gastric cancer susceptibility in persons with H. pylori infection compared with controls without H. pylori infection. IL-10 -819 TT genotype is reversely associated with diffuse-subtype risk but not in intestinal-subtype risk. IL-10 -819 TT genotype is not reversely associated with non-cardia or cardia subtype gastric cancer susceptibility.

Conclusions

IL-10 -819 TT genotype seems to be more protective from gastric cancer in Asians. Whether IL-10 -819 TT genotype may be protective from gastric cancer susceptibility in persons infected with H. pylori or in diffuse-subtype cancer needs further exploring in the future well-designed high quality studies among different ethnicity populations. Direct sequencing should be more used in the future.

Keywords:
Interleukin 10; Gene; Single nucleotide polymorphism; Association; Gastric cancer