Figure 4.

Post-translational regulation and phosphorylation of BCR-ABL on hTERT. (a) Global protein tyrosine-phosphorylation level and BCR-ABL expression in K562 and HL60 cells. (b) Phosphorylation of hTERT at tyrosine residues was higher in K562 cells compared to HL60 cells. (c) Gleevec treatment led to a loss of phosphorylation of hTERT at tyrosine residues