Acid-pulsed competition results. Competition experiments were subjected to daily acid pulsing to model gastric reflux in Barrett's esophagus. Under acid pulsing, CP-A, CP-C, and CP-D BE cell lines show a statistically significant reduction relative to normal squamous cells with 500 μM Vitamin C compared to 0 μM controls when adjusted for multiple testing using a Bonferroni correction (p < 0.05/8 = 0.00625 required for significance). CP-B cells show a reduction at lower concentrations of vitamin C but not at 500 μM. Mean (n = 3) ± standard error of the mean is shown.
Merlo et al. BMC Cancer 2011 11:461 doi:10.1186/1471-2407-11-461