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Open Access Research article

DNA repair gene polymorphisms and risk of chronic atrophic gastritis: a case-control study

Bernd Frank1*, Heiko Müller1, Melanie Nicole Weck1, Norman Klopp2, Thomas Illig2, Elke Raum1 and Hermann Brenner1

Author Affiliations

1 Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany

2 Institute of Epidemiology, Research Centre for Environment and Health, Neuherberg, Germany

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BMC Cancer 2011, 11:440  doi:10.1186/1471-2407-11-440

Published: 11 October 2011

Abstract

Background

Recent studies have reported associations of DNA repair pathway gene variants and risk of various cancers and precancerous lesions, such as chronic atrophic gastritis (CAG).

Methods

A nested case-control study within the German population-based ESTHER cohort was conducted, including 533 CAG cases and 1054 controls. Polymorphisms in eleven DNA repair genes (APEX1, ERCC1, ERCC2/XPD, PARP1 and XRCC1), in CD3EAP/ASE-1 and PPP1R13L were analysed.

Results

No association was disclosed for any of the analysed polymorphisms. Nor did stratified analyses according to ages < 65 and ≥ 65 years show any significant association with CAG risk.

Conclusions

The results of this large German case-control study do not reveal associations of DNA repair pathway polymorphisms and risk of CAG. On the basis of a large number of CAG cases, they do not support associations of DNA repair pathway SNPs with CAG risk, but suggest the need of larger studies to disclose or exclude potential weak associations, or of studies with full coverage of candidate genes.