Additional file 8.
Figure S1. Distribution of nominal p-values for univariate association of the 138 genes identified as over-expressed in OSCC with recurrence. P-values were determined by Cox regression using the maximum expression in any margin of each patient. The empirical null distribution was determined from association of these same genes with 1,000 permutations of the outcome labels. The observed nominal p-values are significantly enriched for small values (p = 0.001, Kolmogorov-Smirnov test). It is worth noting that recurrence was not used at any stage in the selection of these genes.
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Reis et al. BMC Cancer 2011 11:437 doi:10.1186/1471-2407-11-437