Open Access Highly Accessed Research article

Modulation of TRAIL resistance in colon carcinoma cells: Different contributions of DR4 and DR5

Caroline MM van Geelen1, Bodvael Pennarun12, Phuong TK Le1, Elisabeth GE de Vries1 and Steven de Jong1*

Author Affiliations

1 Departments of Medical Oncology and Gastroenterology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands

2 Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands

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BMC Cancer 2011, 11:39  doi:10.1186/1471-2407-11-39

Published: 27 January 2011

Additional files

Additional file 1:

Effects of IFN-γ on c-FLIP cleavage. Western blot analysis of c-FLIP levels in SW948-TR after 48 h preincubation with 1000 U/ml IFN-γ in combination with rhTRAIL (0.1 μg/ml), agonistic DR4 or DR5 antibody (50 nM) treatment for 5 h.

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