Table 4

ORs of breast cancer associated with supplementation of antioxidants, NECSS,Canada,1994-1997

Premenopausal

Postmenopausal



Variable

Cases

Controls

OR † (95% CI)

p trend

Cases

Controls

OR†† (95% CI)

p trend


Multiple vitamin (years)

0.53

0.04

0 (never taken)*

269

249

1.00

654

731

1.00

≤ 2 year

282

294

0.86 (0.67-1.10)

312

335

0.91 (0.75-1.11)

3-9 year

180

177

0.85 (0.64-1.13)

292

268

1.03 (0.83-1.27)

≥ 10 years

135

125

0.93 (0.69-1.27)

238

283

0.74 (0.59-0.92)

Vitamin A (years)

0.26

0.31

0 (never taken)*

690

677

1.00

1235

1350

1.00

≤ 2 year

105

95

1.02 (0.75-1.39)

127

133

0.90 (0.69-1.19)

3-9 year

47

40

1.03 (0.65-1.61)

72

61

1.12 (0.77-1.63)

≥ 10 years

24

33

0.61 (0.35-1.06)

62

73

0.77 (0.53-1.11)

Beta-carotene (years) #

0.86

0.15

0 (never taken)*

675

689

1.00

1219

1348

1.00

≤ 2 year

144

93

1.54 (1.16-2.06)

182

162

1.01 (0.79-1.29)

3-9 year

35

42

0.85 (0.53-1.37)

63

60

1.01 (0.69-1.49)

≥ 10 years

12

21

0.51 (0.24-1.06)

32

47

0.58 (0.36-0.95)

Vitamin C (years) #

0.26

0.07

0 (never taken)*

337

357

1.00

687

792

1.00

≤ 2 year

267

223

1.20 (0.94-1.53)

306

317

0.86 (0.70-1.05)

3-9 year

165

148

1.08 (0.82-1.43)

268

261

0.96 (0.77-1.19)

≥ 10 years

97

117

0.75 (0.54-1.03)

235

247

0.79 (0.63-0.99)

Vitamin E (years) #

0.25

0.05

0 (never taken)*

493

513

1.00

822

935

1.00

≤ 2 year

245

171

1.46 (1.15-1.85)

316

286

1.05 (0.86-1.28)

3-9 year

89

113

0.73 (0.53-1.01)

209

220

0.91 (0.72-1.15)

≥ 10 years

39

48

0.74 (0.47-1.17)

149

176

0.75 (0.58-0.97)

Zinc (years) #

0.004

0.02

0 (never taken)*

736

688

1.00

1297

1420

1.00

≤ 2 year

85

95

0.81 (0.58-1.11)

120

94

1.14 (0.84-1.53)

3-9 year

27

33

0.73 (0.43-1.25)

52

56

0.83 (0.55-1.26)

≥ 10 years

18

29

0.46 (0.25-0.85)

27

47

0.47 (0.28-0.78)

Selenium (years) #

0.59

0.85

0 (never taken)*

755

754

1.00

1355

1504

1.00

≤ 2 year

85

50

1.65 (1.13-2.40)

88

56

1.43 (0.98-2.05)

3-9 year

16

27

0.59 (0.31-1.12)

29

30

0.90 (0.52-1.57)

≥ 10 years

10

14

0.57 (0.25-1.34)

24

27

0.75 (0.42-1.34)


* Reference category

† Adjusted for age, province of residence, education, smoking pack years, alcohol consumption, number of live births, age at menarche, and total energy intake.

†† Adjusted for age, province of residence, education, smoking pack years, alcohol consumption, BMI, recreational physical activity, number of live births, age at menarche, and total energy intake.

# also adjusted for antioxidant intake from diet.

Pan et al. BMC Cancer 2011 11:372   doi:10.1186/1471-2407-11-372

Open Data