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Open Access Case report

Primary leiomyosarcoma of the seminal vesicle: Case report and review of the literature

Cécile Cauvin1, Laurence Moureau-Zabotto1, Bruno Chetaille2, Werner Hilgers3, Yves Denoux4, Jocelyne Jacquemier2, Jérôme Guiramand5, Anthony Sarran6 and François Bertucci78*

Author Affiliations

1 Department of Radiotherapy, Institut Paoli-Calmettes, 27 bd Leï Roure, 13009, Marseille, France

2 Department of Pathology, Institut Paoli-Calmettes, 27 bd Leï Roure, 13009, Marseille, France

3 Department of Medical Oncology, Institut Sainte-Catherine, 1750 ch du Lavarin, 84082, Avignon, France

4 Department of Pathology, Hôpital Foch, 40 rue Worth, 92151 Suresnes, France

5 Department of Surgical Oncology, Institut Paoli-Calmettes, 27 bd Leï Roure, 13009, Marseille, France

6 Department of Radiology, Institut Paoli-Calmettes, 27 bd Leï Roure, 13009, Marseille, France

7 Department of Medical Oncology, Institut Paoli-Calmettes, 27 bd Leï Roure, 13009, Marseille, France

8 University of Mediterranea, 58 bd Charles Livon, 13001, Marseille, France

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BMC Cancer 2011, 11:323  doi:10.1186/1471-2407-11-323

Published: 29 July 2011

Abstract

Background

Primary leiomyosarcoma of the seminal vesicle is exceedingly rare.

Case Presentation

We report a case of a 59-year-old man with tumour detected by rectal symptoms and ultrasonography. Computed tomography and magnetic resonance imaging suggested an origin in the right seminal vesicle. Transperineal biopsy of the tumour revealed leiomyosarcoma. A radical vesiculo-prostactectomy with bilateral pelvic lymphadenectomy was performed. Pathological examination showed a grade 2 leiomyosarcoma of the seminal vesicle. The patient received adjuvant radiotherapy. He developed distant metastases 29 months after diagnosis, and received chemotherapy. Metastatic disease was controlled by second-line gemcitabine-docetaxel combination. Fifty-one months after diagnosis of the primary tumour, and 22 months after the first metastases, the patient is alive with excellent performance status, and multiple asymptomatic stable lung and liver lesions.

Conclusions

We report the eighth case of primary leiomyosarcoma of the seminal vesicle and the first one with a so long follow-up.

Keywords:
leiomyosarcoma; seminal vesicle