Ketogenic diet induces ketosis but does not lower blood glucose levels. LNT-229 cells were implanted into the right striatum of nude mice at day 0. Thereafter, animals were fed either the standard diet or the ketogenic diet. (A) Body weight was measured twice weekly and is presented as mean and standard deviation. (B) Blood levels of 3-hydroxybutyrate and glucose were determined on the day of tumor cell implantation (day 0) and every 7 days thereafter. 3-hydroxybutyrate values in mice fed the ketogenic diet were significantly higher than those in the control group (Bonferroni-adjusted p < 0.05 at all time points after diet change). By contrast, glucose levels did not differ significantly between diet groups. Boxplots depict the median, quartiles and extreme values. Upper and lower whiskers correspond to the highest and lowest values which are not greater than 1.5 times the interquartile range; •, cases with values between 1.5 and 3 times the interquartile range; *, cases with values more than 3 times the interquartile range.
Maurer et al. BMC Cancer 2011 11:315 doi:10.1186/1471-2407-11-315