Table 4

Incidence rate ratios for lung cancer for the parent population stratified for the offspring's route of HIV infection

Cancer, N

Unadjusted IRR (95% CI)

Adjusted IRR* (95% CI)


All fathers of HIV patients**

122/1233

1.38 (1.14 - 1.66)

1.31 (1.09 - 1.58)


Stratification


Route of HIV infection for offspring

Men who have sex with men (MSM)

65/535

1.34 (1.04 - 1.73)

1.24 (0.96 - 1.61)

Heterosexually infected

31/440

1.39 (0.97 - 2.00)

1.31 (0.91 - 1.89)

Injection drug user (IDU)

20/183

1.40 (0.89 - 2.23)

1.63 (1.02 - 2.58)


All mothers of HIV infected***

78/763

1.37 (1.08 - 1.72)

1.35 (1.07 - 1.70)


Stratification


Route of HIV infection for offspring

Men who have sex with men (MSM)

41/342

1.29 (0.93 - 1.78)

1.26 (0.90 - 1.73)

Heterosexually infected

17/262

1.20 (0.73 - 1.96)

1.20 (0.73 - 1.96)

Injection drug user (IDU)

17/112

1.84 (1.10 - 3.06)

2.01 (1.21 - 3.36)


* Adjusted for age at parent index date (continuous variable) as well as year of birth of the parent divided into the following decades: - 1920, 1920-1930, 1930-1940, 1940-1950, 1950 - later.

** There were five cases of lung cancer among fathers of children who had other route of HIV infection and 85 among fathers of population controls.

*** There were one case of lung cancer among mothers of children who had other route of HIV infection

Engsig et al. BMC Cancer 2011 11:272   doi:10.1186/1471-2407-11-272

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