Table 1

Characteristics of HIV patients and population controls with lung cancer

HIV patients

N = 5053,

HIV patients with lung cancer

N = 29,

Population controls with lung cancer

N = 183,

P value*

N (%)

N (%)

N (%)


Male gender

3827 (75.7)

27 (93.1)

156 (85.2)

0.253

Age at time of index date, median (IQR), years

36.6 (30.4 - 44.3)

49.9 (42.7 - 59.7)

50.7 (45.1 - 59.5)

0.554

Age at time of cancer diagnosis, median (IQR), years

-

57.0 (48.8 - 63.2)

58.9 (52.2 - 67.5)

0.192

Native Danes

3619 (71.6)

24 (82.8)

179 (97.8)

> 0.001

Older than 50 years at index date

695 (13.8)

14 (58.3)

98 (53.6)

0.129

Diagnosed with HIV before 1 January 1995

1968 (38.9)

18 (62.1)

Smoker or former smoker in any quantity

2600 (71.1)

29 (100)

Route of HIV infection

Men who have sex with men

2287 (45.3)

12 (41.4)

Heterosexually infected men

934 (18.5)

12 (41.4)

Heterosexually infected women

930 (18.4)

2 (6.9)

Injection drug user

553 (10.9)

3 (10.3)

Other

349 (6.9)

0 (0.0)

Baseline CD4 < 350 cells/μL or AIDS defining event at index date

2655 (52.5)

20 (69.0)

Baseline CD4 cell count, cells/μL, median (IQR)

279 (104 - 480)

230 (86 - 403)


Histological classification of lung cancer

HIV patients with lung cancer

N = 29

Population controls with lung cancer

N = 183

P value


Squamous cell carcinoma

8 (27.6)

36 (19.7)

Small cell carcinoma

4 (13.8)

31 (16.9)

Adenocarcinoma

7 (24.1)

55 (30.1)

Large cell carcinoma

0 (0)

12 (6.5)

Other and unclassified

10 (34.5)**

49 (26.8)***

P value for difference in distribution of HPV site, potential HPV site and potentially unrelated HPV site

0.457


*P value for differences in characteristics between HIV patients and population controls with lung cancer

**3 carcinoma without other specifications (M80103), 3 Non-Large cell carcinomas (M80463), 2 adenosquamos carcinomas (M85603), 1 no microscopically confirmed lung cancer (M99903) and 1 malignant histology unknown (M99993).

***2 neoplasm malignant (M80003), 3 malignant tumor cells (M80013), 3 carcinoma without other specifications (M80103), 22 Non-Large cell carcinomas (M80463), 3 carcinoid tumor, malignant (M82403), 1 neuroendocrine carcinoma (M82463), 1 adenosquamous carcinomas (M85603), 12 not microscopically confirmed lung cancer (M99903) and 2 malignant histology unknown (M99993).

Engsig et al. BMC Cancer 2011 11:272   doi:10.1186/1471-2407-11-272

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