Table 1

Evaluation of cytokine levels in BAL of mice 4 months post-XRT.

Treatment

Groups

IL-1β

IL-4

IL-6

IL-12

(p40/p70)

IL-17

KC

MIG

MIP-1α

VEGF


0%FS

26.7 ± 8.3

28.6 ± 6.3

21.0 ± 5.9

19.2 ± 3.1

0.6 ± 0.2

658.6 ± 39.3

15.3 ± 2.5

25.4 ± 7.8

26.6 ± 4.6

0%FS + XRT

12.1 ± 2.7

17.4 ± 1.0

66.0 ± 42.5

88.1 ± 18.2

0.4 ± 0.1

173.0 ± 47.0

11.4 ± 4.2

18.5 ± 3.7

43.9 ± 4.5

10%FS

14.4 ± 5.1

20.4 ± 2.3

16.6 ± 2.0

12.9 ± 1.3

0.4 ± 0.1

730.7 ± 58.4

14.6 ± 4.4

16.5 ± 3.0

21.1 ± 2.9#

10%FS + XRT (0 Day)

12.4 ± 0.8

18.2 ± 0.3

20.4 ± 1.1$

51.1 ± 13.3$

0.6 ± 0.1

521.0 ± 165.0*

20.9 ± 4.9

13.3 ± 1.5

21.4 ± 3.8#

10%FS + XRT (-3 wks)

14.7 ± 1.5

17.9 ± 0.6

28.0 ± 6.4

54.2 ± 13.6*

0.9 ± 0.3*

396.0 ± 49.3

14.8 ± 2.8

15.7 ± 1.6

16.9 ± 3.4#

10%FS + XRT (+2 wks)

13.1 ± 2.9

15.9 ± 1.0

16.6 ± 1.7*

43.2 ± 7.9*

0.3 ± 0.1§§

380.5 ± 162.7

7.2 ± 2.0

14.5 ± 1.7

13.4 ± 1.3#

10%FS + XRT (+4 wks)

7.4 ± 1.0

16.6 ± 0.6

13.0 ± 1.8*

16.2 ± 1.2# §

0.1 ± 0.0§§

444.0 ± 66.8

8.8 ± 1.6

10.0 ± 1.2

6.8 ± 2.2#

10%FS + XRT (+6 wks)

7.7 ± 1.2

16.5 ± 0.9

15.3 ± 1.7$

26.8 ± 7.1#

0.2 ± 0.0§§

264.7 ± 150.7

9.0 ± 4.8

10.0 ± 2.1

11.7 ± 1.8#


Mice were fed with 0% or 10%FS diet prior (-3 weeks) or post (+2, +4, +6 weeks) X-ray radiation therapy (XRT) and sacrificed after 4 months. Lungs were lavaged and cytokine levels in BAL were measured. Data is represented mean ± SEM of two independent experiments (n = 15 and 25 mice in non-irradiated and irradiated groups, respectively). Values are mean ± SEM of two independent experiments. n = 15 and 25 in non irradiated and irradiated groups respectively.

$

    p
≤ 0.05, *
    p
≤ 0.01, #
    p
≤ 0.0005, for 0%FS irradiated vs. 10%FS irradiated groups.

§p ≤ 0.05, §§ p ≤ 0.01 for 10%FS given preventively to XRT Vs 10%FS started therapeutically post-XRT.

Christofidou-Solomidou et al. BMC Cancer 2011 11:269   doi:10.1186/1471-2407-11-269

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