Reovirus induced cell kill is enhanced by the addition of docetaxel. PC3 (a) and Du 145 cells (b) were treated with reovirus alone (diamonds), docetaxel alone (squares) or a combination of the two (triangles) at the doses indicated for 48 h. Survival was measured at this time using MTS. In both cell lines tested, the combined treatment significantly reduced cell survival compared to either treatment alone (2-way ANOVA, p < 0.0001).
Heinemann et al. BMC Cancer 2011 11:221 doi:10.1186/1471-2407-11-221