Table 2

Immunohistochemical findings for each of the three characteristic components of the tumor.

Epithelioid cells

Spindle-shaped cells

Ganglion-like cells


S-100

3.8% (4/104)

94.2% (98/104)

9.3% (9/97)

Synaptophysin

90.0% (36/40)

64.7% (22/34)

94.3% (33/35)

Chromogranin A

67.4% (60/89)

7.2% (6/83)

15.4% (12/78)

Neuron specific enolase

93.9% (77/82)

84.0% (63/75)

84.0% (63/75)

Cytokeratins

48.3% (28/58)

4.0% (2/50)

3.9% (2/51)

Vimentin

14.3% (1/7)

50.0% (2/4)

0.0% (0/6)

Neuron fiber

20.9% (14/67)

66.7% (44/66)

24.6% (16/65)

Pancreatic polypeptide

89.7% (70/78)

0.0% (0/72)

22.2% (16/72)

Somatostatin

81.8% (63/77)

8.7% (6/69)

44.1% (30/68)

Serotonin

22.0% (13/59)

0.0% (0/55)

16.7% (9/54)

Vasoactive intestinal polypeptide

12.1% (4/33)

12.9% (4/31)

9.7% (3/31)

Glucagon

6.4% (3/47)

0.0% (0/44)

2.4% (1/42)

Gastrin

5.9% (4/68)

0.0% (0/64)

0.0% (0/63)

Insulin

2.2% (1/46)

0.0% (0/41)

0.0% (0/42)


Positive or negative findings from immunohistochemistry in 173 extracted duodenal gangliocytic paraganglioma are summarized.

Okubo et al. BMC Cancer 2011 11:187   doi:10.1186/1471-2407-11-187

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