Table 4

Relative risks for family size and age at diagnosis

Age at diagnosis < 50 years

Age at diagnosis ≥ 50 years

All

Family size

Ref

Family size

Ref

Family size

Ref

Cancer site

(ICD-7 code)

N

RR

(95% CI)

N

N

RR

(95% CI)

N

N

RR

(95% CI)

N


Upper aero-digestive tract

(140+)

694

1.00

(0.81-1.23)

104

1068

0.96

(0.84-1.09)

316

1762

0.97

(0.87-1.09)

420


Salivary glands

(142)

222

0.85

(0.62-1.17)

38

117

0.87

(0.61-1.24)

38

339

0.87

(0.68-1.10)

76


Esophagus

(150)

85

0.52

(0.33-0.82)

22

528

0.99

(0.82-1.18)

155

613

0.92

(0.77-1.10)

177


Stomach

(151)

423

0.91

(0.68-1.21)

70

1009

1.17

(1.02-1.34)

253

1432

1.11

(0.96-1.29)

323


Small intestine

(152)

140

0.76

(0.53-1.09)

29

282

1.14

(0.91-1.44)

71

422

1.03

(0.84-1.27)

100


Colon

(153)

1633

1.01

(0.88-1.17)

233

3213

0.95

(0.89-1.02)

1042

4846

0.97

(0.91-1.03)

1275


Rectum

(154/1541)

632

1.13

(0.78-1.65)

87

2152

0.96

(0.88-1.04)

672

2784

0.98

(0.88-1.09)

759


Anus

(1541)

105

0.93

(0.59-1.48)

17

171

1.03

(0.75-1.41)

47

276

1.01

(0.79-1.30)

64


Liver and gallbladder

(155, 156)

376

1.23

(0.92-1.65)

43

972

0.95

(0.83-1.08)

302

1348

0.99

(0.88-1.11)

345


Pancreas

(157)

231

1.00

(0.72-1.40)

31

1176

0.93

(0.81-1.06)

369

1407

0.94

(0.84-1.05)

400


Nose

(160)

85

1.24

(0.58-2.67)

10

95

1.53

(0.96-2.44)

19

180

1.39

(0.89-2.17)

29


Larynx

(161)

111

1.09

(0.64-1.86)

18

304

1.15

(0.91-1.45)

76

415

1.15

(0.90-1.47)

94


Lung

(162, 163)

926

1.20

(0.97-1.48)

117

4254

0.95

(0.89-1.02)

1290

5180

0.99

(0.93-1.05)

1407


Breast

(170)

8325

0.91

(0.70-1.20)

1506

11473

0.98

(0.95-1.02)

3215

19798

0.96

(0.86-1.08)

4721


Cervix

(171)

2782

0.97

(0.82-1.14)

424

488

0.82

(0.69-0.98)

158

3270

0.93

(0.82-1.05)

582


Endometrium

(172)

412

0.67

(0.55-0.81)

122

2145

0.78

(0.72-0.84)

821

2557

0.76

(0.71-0.82)

943


Uterus

(173, 174)

258

1.29

(1.05-1.60)

33

208

0.94

(0.77-1.15)

64

466

1.07

(0.93-1.24)

97


Ovary

(175)

1532

0.98

(0.84-1.16)

238

1542

0.99

(0.89-1.11)

441

3074

0.99

(0.90-1.09)

679


Other female genital

(176)

195

1.32

(0.95-1.83)

23

189

1.02

(0.76-1.38)

50

384

1.14

(0.92-1.40)

73


Prostate

(177)

144

0.85

(0.60-1.21)

24

9489

0.98

(0.95-1.01)

3047

9633

0.98

(0.95-1.02)

3071


Testis

(178)

2857

0.87

(0.80-0.94)

393

139

0.96

(0.75-1.22)

38

2996

0.87

(0.81-0.94)

431


Other male genital

(179)

114

1.08

(0.80-1.46)

17

145

1.16

(0.91-1.49)

34

259

1.14

(0.95-1.36)

51


Kidney

(180)

1112

1.01

(0.86-1.19)

159

1460

0.99

(0.88-1.11)

440

2572

0.99

(0.91-1.08)

599


Urinary bladder

(181)

834

1.04

(0.88-1.22)

141

2295

0.94

(0.87-1.02)

751

3129

0.96

(0.89-1.03)

892


Melanoma

(190)

4919

0.85

(0.78-0.93)

822

2740

0.96

(0.88-1.04)

802

7659

0.90

(0.84-0.96)

1624


Squamous cell skin

(191)

708

0.98

(0.80-1.21)

109

1433

0.89

(0.81-0.97)

514

2141

0.90

(0.82-0.99)

623


Eye

(192)

480

0.97

(0.75-1.25)

60

181

0.96

(0.72-1.28)

53

661

0.97

(0.80-1.18)

113


Nervous system

(193)

6286

1.16

(1.05-1.29)

658

2192

1.06

(0.96-1.16)

564

8478

1.13

(1.05-1.21)

1222


Thyroid gland

(194)

1496

1.00

(0.87-1.14)

219

356

1.12

(0.89-1.41)

89

1852

1.03

(0.91-1.16)

308


Endocrine glands

(195)

1718

1.00

(0.88-1.14)

256

1189

1.00

(0.88-1.13)

331

2907

1.01

(0.92-1.10)

587


Bone

(196)

821

1.04

(0.84-1.29)

91

69

1.12

(0.71-2.17)

15

890

1.08

(0.89-1.31)

106


Connective tissue

(197)

1013

0.96

(0.81-1.14)

135

318

0.94

(0.76-1.17)

97

1331

0.95

(0.83-1.09)

232


Non-Hodgkin lymphoma

(200, 202)

2163

1.00

(0.85-1.18)

282

2038

0.97

(0.88-1.07)

602

4201

0.98

(0.90-1.07)

884


Hodgkin lymphoma

(201)

1736

0.94

(0.81-1.09)

212

141

0.86

(0.62-1.20)

44

1877

0.93

(0.81-1.07)

256


Myeloma

(203)

211

1.32

(0.89-1.94)

25

660

0.96

(0.82-1.11)

207

871

1.00

(0.87-1.15)

232


Leukaemia

(204 - 209)

3775

1.30

(1.07-1.59)

343

1429

1.06

(0.95-1.18)

397

5204

1.20

(1.08-1.33)

740


Other and unspecified sites

(other)

707

1.00

(0.81-1.24)

97

1766

0.90

(0.80-1.03)

577

2473

0.93

(0.84-1.02)

674


Any site

(any)

50261

0.97

(0.94-1.00)

7208

59426

0.99

(0.94-1.04)

18001

109687

0.99

(0.96-1.02)

25209


Reference group: one-child families. Bold type, 95% CI does not include 1.00. Poisson regression adjusted for age, sex, period, region, socioeconomic status. Ref: reference, N: number of cases

Bevier et al. BMC Cancer 2011 11:163   doi:10.1186/1471-2407-11-163

Open Data