Table 4 |
||||||||||
|
Relative risks for family size and age at diagnosis |
||||||||||
|
Age at diagnosis < 50 years |
Age at diagnosis ≥ 50 years |
All |
||||||||
|
Family size |
Ref |
Family size |
Ref |
Family size |
Ref |
|||||
|
Cancer site |
(ICD-7 code) |
N |
RR (95% CI) |
N |
N |
RR (95% CI) |
N |
N |
RR (95% CI) |
N |
|
|
||||||||||
|
Upper aero-digestive tract |
(140+) |
694 |
1.00 (0.81-1.23) |
104 |
1068 |
0.96 (0.84-1.09) |
316 |
1762 |
0.97 (0.87-1.09) |
420 |
|
|
||||||||||
|
Salivary glands |
(142) |
222 |
0.85 (0.62-1.17) |
38 |
117 |
0.87 (0.61-1.24) |
38 |
339 |
0.87 (0.68-1.10) |
76 |
|
|
||||||||||
|
Esophagus |
(150) |
85 |
0.52 (0.33-0.82) |
22 |
528 |
0.99 (0.82-1.18) |
155 |
613 |
0.92 (0.77-1.10) |
177 |
|
|
||||||||||
|
Stomach |
(151) |
423 |
0.91 (0.68-1.21) |
70 |
1009 |
1.17 (1.02-1.34) |
253 |
1432 |
1.11 (0.96-1.29) |
323 |
|
|
||||||||||
|
Small intestine |
(152) |
140 |
0.76 (0.53-1.09) |
29 |
282 |
1.14 (0.91-1.44) |
71 |
422 |
1.03 (0.84-1.27) |
100 |
|
|
||||||||||
|
Colon |
(153) |
1633 |
1.01 (0.88-1.17) |
233 |
3213 |
0.95 (0.89-1.02) |
1042 |
4846 |
0.97 (0.91-1.03) |
1275 |
|
|
||||||||||
|
Rectum |
(154/1541) |
632 |
1.13 (0.78-1.65) |
87 |
2152 |
0.96 (0.88-1.04) |
672 |
2784 |
0.98 (0.88-1.09) |
759 |
|
|
||||||||||
|
Anus |
(1541) |
105 |
0.93 (0.59-1.48) |
17 |
171 |
1.03 (0.75-1.41) |
47 |
276 |
1.01 (0.79-1.30) |
64 |
|
|
||||||||||
|
Liver and gallbladder |
(155, 156) |
376 |
1.23 (0.92-1.65) |
43 |
972 |
0.95 (0.83-1.08) |
302 |
1348 |
0.99 (0.88-1.11) |
345 |
|
|
||||||||||
|
Pancreas |
(157) |
231 |
1.00 (0.72-1.40) |
31 |
1176 |
0.93 (0.81-1.06) |
369 |
1407 |
0.94 (0.84-1.05) |
400 |
|
|
||||||||||
|
Nose |
(160) |
85 |
1.24 (0.58-2.67) |
10 |
95 |
1.53 (0.96-2.44) |
19 |
180 |
1.39 (0.89-2.17) |
29 |
|
|
||||||||||
|
Larynx |
(161) |
111 |
1.09 (0.64-1.86) |
18 |
304 |
1.15 (0.91-1.45) |
76 |
415 |
1.15 (0.90-1.47) |
94 |
|
|
||||||||||
|
Lung |
(162, 163) |
926 |
1.20 (0.97-1.48) |
117 |
4254 |
0.95 (0.89-1.02) |
1290 |
5180 |
0.99 (0.93-1.05) |
1407 |
|
|
||||||||||
|
Breast |
(170) |
8325 |
0.91 (0.70-1.20) |
1506 |
11473 |
0.98 (0.95-1.02) |
3215 |
19798 |
0.96 (0.86-1.08) |
4721 |
|
|
||||||||||
|
Cervix |
(171) |
2782 |
0.97 (0.82-1.14) |
424 |
488 |
0.82 (0.69-0.98) |
158 |
3270 |
0.93 (0.82-1.05) |
582 |
|
|
||||||||||
|
Endometrium |
(172) |
412 |
0.67 (0.55-0.81) |
122 |
2145 |
0.78 (0.72-0.84) |
821 |
2557 |
0.76 (0.71-0.82) |
943 |
|
|
||||||||||
|
Uterus |
(173, 174) |
258 |
1.29 (1.05-1.60) |
33 |
208 |
0.94 (0.77-1.15) |
64 |
466 |
1.07 (0.93-1.24) |
97 |
|
|
||||||||||
|
Ovary |
(175) |
1532 |
0.98 (0.84-1.16) |
238 |
1542 |
0.99 (0.89-1.11) |
441 |
3074 |
0.99 (0.90-1.09) |
679 |
|
|
||||||||||
|
Other female genital |
(176) |
195 |
1.32 (0.95-1.83) |
23 |
189 |
1.02 (0.76-1.38) |
50 |
384 |
1.14 (0.92-1.40) |
73 |
|
|
||||||||||
|
Prostate |
(177) |
144 |
0.85 (0.60-1.21) |
24 |
9489 |
0.98 (0.95-1.01) |
3047 |
9633 |
0.98 (0.95-1.02) |
3071 |
|
|
||||||||||
|
Testis |
(178) |
2857 |
0.87 (0.80-0.94) |
393 |
139 |
0.96 (0.75-1.22) |
38 |
2996 |
0.87 (0.81-0.94) |
431 |
|
|
||||||||||
|
Other male genital |
(179) |
114 |
1.08 (0.80-1.46) |
17 |
145 |
1.16 (0.91-1.49) |
34 |
259 |
1.14 (0.95-1.36) |
51 |
|
|
||||||||||
|
Kidney |
(180) |
1112 |
1.01 (0.86-1.19) |
159 |
1460 |
0.99 (0.88-1.11) |
440 |
2572 |
0.99 (0.91-1.08) |
599 |
|
|
||||||||||
|
Urinary bladder |
(181) |
834 |
1.04 (0.88-1.22) |
141 |
2295 |
0.94 (0.87-1.02) |
751 |
3129 |
0.96 (0.89-1.03) |
892 |
|
|
||||||||||
|
Melanoma |
(190) |
4919 |
0.85 (0.78-0.93) |
822 |
2740 |
0.96 (0.88-1.04) |
802 |
7659 |
0.90 (0.84-0.96) |
1624 |
|
|
||||||||||
|
Squamous cell skin |
(191) |
708 |
0.98 (0.80-1.21) |
109 |
1433 |
0.89 (0.81-0.97) |
514 |
2141 |
0.90 (0.82-0.99) |
623 |
|
|
||||||||||
|
Eye |
(192) |
480 |
0.97 (0.75-1.25) |
60 |
181 |
0.96 (0.72-1.28) |
53 |
661 |
0.97 (0.80-1.18) |
113 |
|
|
||||||||||
|
Nervous system |
(193) |
6286 |
1.16 (1.05-1.29) |
658 |
2192 |
1.06 (0.96-1.16) |
564 |
8478 |
1.13 (1.05-1.21) |
1222 |
|
|
||||||||||
|
Thyroid gland |
(194) |
1496 |
1.00 (0.87-1.14) |
219 |
356 |
1.12 (0.89-1.41) |
89 |
1852 |
1.03 (0.91-1.16) |
308 |
|
|
||||||||||
|
Endocrine glands |
(195) |
1718 |
1.00 (0.88-1.14) |
256 |
1189 |
1.00 (0.88-1.13) |
331 |
2907 |
1.01 (0.92-1.10) |
587 |
|
|
||||||||||
|
Bone |
(196) |
821 |
1.04 (0.84-1.29) |
91 |
69 |
1.12 (0.71-2.17) |
15 |
890 |
1.08 (0.89-1.31) |
106 |
|
|
||||||||||
|
Connective tissue |
(197) |
1013 |
0.96 (0.81-1.14) |
135 |
318 |
0.94 (0.76-1.17) |
97 |
1331 |
0.95 (0.83-1.09) |
232 |
|
|
||||||||||
|
Non-Hodgkin lymphoma |
(200, 202) |
2163 |
1.00 (0.85-1.18) |
282 |
2038 |
0.97 (0.88-1.07) |
602 |
4201 |
0.98 (0.90-1.07) |
884 |
|
|
||||||||||
|
Hodgkin lymphoma |
(201) |
1736 |
0.94 (0.81-1.09) |
212 |
141 |
0.86 (0.62-1.20) |
44 |
1877 |
0.93 (0.81-1.07) |
256 |
|
|
||||||||||
|
Myeloma |
(203) |
211 |
1.32 (0.89-1.94) |
25 |
660 |
0.96 (0.82-1.11) |
207 |
871 |
1.00 (0.87-1.15) |
232 |
|
|
||||||||||
|
Leukaemia |
(204 - 209) |
3775 |
1.30 (1.07-1.59) |
343 |
1429 |
1.06 (0.95-1.18) |
397 |
5204 |
1.20 (1.08-1.33) |
740 |
|
|
||||||||||
|
Other and unspecified sites |
(other) |
707 |
1.00 (0.81-1.24) |
97 |
1766 |
0.90 (0.80-1.03) |
577 |
2473 |
0.93 (0.84-1.02) |
674 |
|
|
||||||||||
|
Any site |
(any) |
50261 |
0.97 (0.94-1.00) |
7208 |
59426 |
0.99 (0.94-1.04) |
18001 |
109687 |
0.99 (0.96-1.02) |
25209 |
|
|
||||||||||
|
Reference group: one-child families. Bold type, 95% CI does not include 1.00. Poisson regression adjusted for age, sex, period, region, socioeconomic status. Ref: reference, N: number of cases |
||||||||||
|
Bevier et al. BMC Cancer 2011 11:163 doi:10.1186/1471-2407-11-163 |
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