Table 3

Relative risks for birth order and age at diagnosis

Age at diagnosis < 50 years

Age at diagnosis ≥ 50 years

All

Birth order

Ref

Birth order

Ref

Birth order

Ref

Cancer site

(ICD-7 code)

N

RR

(95% CI)

N

N

RR

(95% CI)

N

N

RR

(95% CI)

N


Upper aero-digestive tract

(140+)

402

0.95

(0.82-1.09)

396

577

1.09

(0.98-1.21)

807

979

1.04

(0.95-1.14)

1203


Salivary glands

(142)

119

0.79

(0.63-0.99)

141

59

0.93

(0.65-1.33)

96

178

0.85

(0.70-1.04)

237


Esophagus

(150)

55

0.89

(0.59-1.37)

52

248

0.89

(0.75-1.05)

435

303

0.89

(0.76-1.05)

487


Stomach

(151)

261

1.03

(0.84-1.26)

232

505

1.07

(0.95-1.19)

757

766

1.06

(0.94-1.20)

989


Small intestine

(152)

84

0.94

(0.71-1.24)

85

147

1.12

(0.92-1.36)

206

231

1.07

(0.91-1.26)

291


Colon

(153)

938

0.94

(0.85-1.04)

928

1532

0.97

(0.91-1.04)

2723

2470

0.97

(0.91-1.02)

3651


Rectum

(154/1541)

376

1.03

(0.85-1.26)

343

1084

1.03

(0.96-1.11)

1740

1460

1.03

(0.95-1.12)

2083


Anus

(1541)

66

1.08

(0.77-1.50)

56

85

0.95

(0.74-1.24)

133

151

1.02

(0.83-1.24)

189


Liver and gallbladder

(155, 156)

217

0.95

(0.80-1.14)

202

467

0.92

(0.82-1.04)

807

684

0.94

(0.85-1.04)

1009


Pancreas

(157)

134

0.88

(0.69-1.12)

128

573

0.93

(0.81-1.07)

972

707

0.93

(0.84-1.03)

1100


Nose

(160)

49

0.99

(0.64-1.52)

46

47

1.19

(0.85-1.67)

67

96

1.05

(0.76-1.45)

113


Larynx

(161)

58

0.82

(0.61-1.10)

71

153

1.05

(0.83-1.32)

227

211

1.00

(0.83-1.19)

298


Lung

(162, 163)

589

1.17

(1.04-1.31)

454

2201

1.03

(0.97-1.09)

3343

2790

1.08

(1.02-1.13)

3797


Breast

(170)

5053

1.03

(0.82-1.28)

4778

5937

0.98

(0.95-1.01)

8751

10990

1.00

(0.91-1.11)

13529


Cervix

(171)

1609

0.95

(0.85-1.06)

1597

245

0.83

(0.71-0.97)

401

1854

0.93

(0.85-1.02)

1998


Endometrium

(172)

213

0.72

(0.64-0.81)

1042

321

0.87

(0.83-0.92)

1924

1255

0.85

(0.81-0.90)

2245


Uterus

(173, 174)

140

0.91

(0.79-1.04)

151

106

0.99

(0.82-1.19)

166

246

0.95

(0.85-1.06)

317


Ovary

(175)

902

0.98

(0.88-1.08)

868

806

1.03

(0.95-1.13)

1177

1708

1.01

(0.94-1.09)

2045


Other female genital

(176)

128

1.34

(1.09-1.64)

90

101

1.03

(0.85-1.26)

138

229

1.20

(1.04-1.38)

228


Prostate

(177)

92

1.04

(0.83-1.31)

76

4552

1.03

(1.00-1.06)

7984

4644

1.03

(1.00-1.06)

8060


Testis

(178)

1668

0.90

(0.84-0.97)

1582

65

0.78

(0.60-1.02)

112

1733

0.89

(0.83-0.95)

1694


Other male genital

(179)

71

1.15

(0.94-1.42)

60

81

1.22

(1.00-1.48)

98

152

1.20

(1.05-1.38)

158


Kidney

(180)

663

1.00

(0.90-1.10)

608

716

0.99

(0.89-1.10)

1184

1379

0.99

(0.92-1.06)

1792


Urinary bladder

(181)

489

1.02

(0.90-1.16)

486

1082

0.94

(0.88-1.02)

1964

1571

0.97

(0.91-1.04)

2450


Melanoma

(190)

2789

0.88

(0.83-0.95)

2952

1310

0.87

(0.81-0.93)

2232

4099

0.88

(0.84-0.92)

5184


Squamous cell skin

(191)

412

0.97

(0.84-1.12)

405

638

0.87

(0.79-0.95)

1309

1050

0.90

(0.83-0.98)

1714


Eye

(192)

297

1.04

(0.89-1.22)

243

88

0.90

(0.71-1.15)

146

385

1.01

(0.88-1.15)

389


Nervous system

(193)

3730

1.00

(0.95-1.06)

3214

1126

0.99

(0.92-1.07)

1630

4856

1.01

(0.96-1.06)

4844


Thyroid

gland

(194)

821

0.86

(0.79-0.95)

894

156

0.79

(0.64-0.97)

289

977

0.85

(0.78-0.92)

1183


Endocrine glands

(195)

1013

0.99

(0.91-1.09)

961

568

0.87

(0.78-0.98)

952

1581

0.95

(0.89-1.02)

1913


Bone

(196)

500

1.06

(0.94-1.20)

412

37

1.11

(0.69-1.79)

47

537

1.08

(0.95-1.22)

459


Connective tissue

(197)

572

0.88

(0.78-0.98)

576

161

1.00

(0.82-1.21)

254

733

0.90

(0.82-0.99)

830


Non-Hodgkin lymphoma

(200, 202)

1330

1.06

(0.97-1.15)

1115

1029

0.99

(0.91-1.08)

1611

2359

1.03

(0.97-1.10)

2726


Hodgkin lymphoma

(201)

1001

0.92

(0.84-1.01)

947

76

1.00

(0.75-1.33)

109

1077

0.93

(0.85-1.01)

1056


Myeloma

(203)

119

0.94

(0.74-1.19)

117

332

1.04

(0.89-1.21)

535

451

1.02

(0.89-1.15)

652


Leukaemia

(204 - 209)

2208

0.98

(0.90-1.06)

1910

709

1.02

(0.93-1.12)

1117

2917

1.00

(0.94-1.07)

3027


Other and unspecified sites

(other)

406

0.91

(0.79-1.04)

398

838

0.89

(0.80-0.99)

1505

1244

0.91

(0.84-0.98)

1903


Any site

(any)

29574

0.97

(0.94-0.99)

27895

29479

0.96

(0.93-1.00)

47948

59053

0.97

(0.95-1.00)

75843


Reference group: first born child. Bold type, 95% CI does not include 1.00. Poisson regression adjusted for age, sex, period, region, socioeconomic status. Ref.: reference, N:number of cases

Bevier et al. BMC Cancer 2011 11:163   doi:10.1186/1471-2407-11-163

Open Data