Open Access Highly Accessed Research article

Inhibition of nuclear factor kappa-B signaling reduces growth in medulloblastoma in vivo

Susan E Spiller12*, Naomi J Logsdon1, Lindsey A Deckard1 and Harald Sontheimer23

Author Affiliations

1 Department of Pediatrics, University of Alabama at Birmingham, 1600 7th Ave S., Birmingham, AL 35294, USA

2 Civitan International Research Center 1719 6thAve. S., Birmingham, AL 35294, USA

3 Department of Neurobiology, University of Alabama at Birmingham, 911 Shelby Biomedical Research Building, 1825 University Blvd, Birmingham, AL 35294, USA

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BMC Cancer 2011, 11:136  doi:10.1186/1471-2407-11-136

Published: 14 April 2011

Additional files

Additional File 1:

Supplemental figure. A - Construct for Tet-off dnIκB used in D425 cells to create 4H10 cells B - Neurospheres cultured in medium containing PDTC for 24 hours (photos at 10X) C - Transient transfection with p5X NFκB -Luc demonstrates diminished NFκB induction with dnIκB construct activated in 4H10 cells by removing DOX.

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