Table 2 |
||||
|
Risk of lung cancer in relation to MDM2 SNP309 and p53 codon 72 polymorphisms |
||||
|
Genotype |
Cases (n = 123) |
Controls (n = 159) |
Age- and birthplace-adjusted1odds ratio (95% CI) |
|
|
|
||||
|
No. (%) |
No. (%) |
|||
|
|
||||
|
MDM2 SNP309 |
||||
|
GG |
29 (23.6) |
51 (32.1) |
1.00 |
|
|
TG |
65 (52.8) |
83 (52.2) |
1.42 (0.80-2.52) |
|
|
TT |
29 (23.6) |
25 (15.7) |
2.10 (1.01-4.36) |
|
|
P53 codon 72 |
||||
|
Arg/Arg |
28 (22.8) |
42 (26.1) |
1.00 |
|
|
Arg/Pro |
69 (56.1) |
88 (54.7) |
1.21 (0.67-2.17) |
|
|
Pro/Pro |
26 (21.1) |
31 (19.3) |
1.44 (0.70-3.00) |
|
|
Combined genotype2 |
||||
|
P53 codon 72 |
MDM2 SNP309 |
|||
|
Arg/Arg |
GG/TG |
24 (85.7%) |
32 (76.2%) |
1.00 |
|
TT |
4 (14.3%) |
10 (23.8%) |
0.58 (0.15-2.22) |
|
|
ArgPro/ProPro |
GG/TG |
69 (73.4%) |
102 (87.2%) |
1.00 |
|
TT |
25 (26.6%) |
15 (12.8%) |
2.42 (1.16-5.03) |
|
|
|
||||
|
1 Adjusted for age in years and birthplace (China-born, Singapore/Malaysia-born). All individuals were lifetime non-smoker Chinese women. 2 P (interaction) = 0.06 |
||||
|
Chua et al. BMC Cancer 2010 10:88 doi:10.1186/1471-2407-10-88 |
||||
