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Open Access Case report

Bladder metastases of appendiceal mucinous adenocarcinoma: a case presentation

Gianluigi Taverna1*, Matteo Corinti1, Piergiuseppe Colombo2, Fabio Grizzi3, Mauro Severo1, Alessando Piccinelli1, Guido Giusti1, Alessio Benetti1, Paolo A Zucali4 and Pierpaolo Graziotti1

Author Affiliations

1 Department of Urology, Via Manzoni 56 - 20089 Rozzano, Milan, Italy

2 Department of Pathology, Via Manzoni 56 - 20089 Rozzano, Milan, Italy

3 Laboratories of Quantitative Medicine, Via Manzoni 56 - 20089 Rozzano, Milan, Italy

4 Department of Medical Oncology, IRCCS Istituto Clinico Humanitas, Via Manzoni 56 - 20089 Rozzano, Milan, Italy

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BMC Cancer 2010, 10:62  doi:10.1186/1471-2407-10-62

Published: 23 February 2010

Abstract

Background

Appendiceal adenocarcinoma is rare with a frequency of 0.08% of all surgically removed appendices. Few cases of appendiceal carcinoma infiltrating the bladder wall for spatial contiguity have been documented.

Case Presentation

A case is reported of a 45-years old woman with mucinous cystadenocarcinoma of the appendix with bladder metastasis. Although ultrasonography and voided urinary cytology were negative, abdomen computed tomography (CT) scan and cystoscopy and subsequent pathological examination revealed a mass exclusively located in the anterior wall of the bladder. Histopathology of the transurethral bladder resection revealed a bladder adenocarcinoma [6 cm (at the maximum diameter) × 2,5 cm; approximate weight: 10 gr] with focal mucinous aspects penetrating the muscle and perivisceral fat. Laparotomy evidenced the presence of a solid mass of the appendix (2,5 cm × 3 cm × 2 cm) extending to the loco-regional lymph nodes. Appendectomy and right hemicolectomy, linfoadenectomy and partial cystectomy were performed. The subsequent pathological examination revealed a mucinous cystadenocarcinoma of the appendix with metastatic cells colonising the anterior bladder wall and several colic lymph nodes.

Conclusions

The rarity of the appendiceal carcinoma invading the urinary bladder and its usual involvement of nearest organs and the posterior bladder wall, led us to describe this case which demonstrates the ability of the appendiceal cancer to metastasize different regions of urinary bladder.