Kaplan-Meier plots of disease-free (A) and overall (B) survival in primary resected Barrett's cancer patients as a function of tumor infiltrating lymphocyte (TIL) density. Survival differences were found when high and low densities of CD3+, CD8+, and CD45RO+ were combined. In each cohort high and low TIL densities were plotted according to the corresponding cut-off values. Blue lines indicate patients with tumors containing high CD3+CD8+CD45RO+ densities, red lines indicate patients whose tumors had low densities of CD3+CD8+CD45RO+ TILs. P values are calculated by log-rank tests. The 5-year disease-free survival rate for patients with high levels of CD3+CD8+CD45RO+ TILs was 42.9% compared to 10.0% for patients with low levels of CD3+CD8+CD45RO+ TILs (overall survival: 51.3% versus 11.7%).
Rauser et al. BMC Cancer 2010 10:608 doi:10.1186/1471-2407-10-608