General role of aCD4 or IFN-γ/TNF-α combination in the radio-sensitization of cancer cells. Cancer cells from various histology were pre-treated with aCD4S or the combination of 160 U/ml of IFN-γ and 11.2 ng/ml of TNF-α were used to presensitize tumor cells for 3 days, followed by irradiation (4 Gy for a cervical cell line CaSki and prostate cancer cell line DU145, and 8 Gy for a glioma cell line U373). Similar results were seen in two independent experiments. All experiments were performed in triplicate and repeated at least 2 times. Data represent mean values of each triplicate ± S.D. Groups labeled * (p < 0.05) and ** (P < 0.01) were compared to irradiation alone group.
Wang et al. BMC Cancer 2010 10:60 doi:10.1186/1471-2407-10-60