PDGF-B overexpression induced gliomas in NG2-KO mice. (A) Survival curves following PDGF-B embryonic transduction of NG2-KO (green line) and wild type (black line) mice. The Log-rank test performed on the survival curves of NG2-KO and wild type animals showed that there are no significant differences (Log-rank Test = N.S.) between the two distributions. (B-C) Fluorescence images of PDGF-B-induced tumors in NG2-KO (B) and wild type (C) mice. (D-M) Coronal sections of tumors obtained in NG2-KO (D, F, F', H, I) or wild type (E, G, G', L, M) mice stained with DAPI for nuclear staining in blue and antibodies for the indicated antigens (D-G', I, M) or with hematoxylin and eosin (H, L). F' and G' are magnifications of the insets in figures F and G respectively, arrowheads point infiltrating cells. NT: non-tumor zone; T: highly cellularized tumor zone. Scale bars: 0.5 mm (B-E); 100 μm (F-M).
Terrile et al. BMC Cancer 2010 10:550 doi:10.1186/1471-2407-10-550