Polymorphisms of XRCC4 are involved in reduced colorectal cancer risk in Chinese schizophrenia patients
1 Bio-X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China
2 Institutes of Biomedical Sciences Fudan University, 138 Yixueyuan Road, Shanghai 200032, China
3 Institute for Nutritional Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China
4 Shanghai Institute of Mental Health, 600 South Wan Ping Road, Shanghai 200030, China
5 Department of General Surgery, The Affiliated Shanghai First People's Hospital of Shanghai Jiao Tong University, 100 Hai Ning Road, Shanghai 200080, China
6 Shanxi Cancer Hospital, 3 Zhi Gong Xin Street, Taiyuan 320013, China
BMC Cancer 2010, 10:523 doi:10.1186/1471-2407-10-523Published: 4 October 2010
Genetic factors related to the regulation of apoptosis in schizophrenia patients may be involved in a reduced vulnerability to cancer. XRCC4 is one of the potential candidate genes associated with schizophrenia which might induce colorectal cancer resistance.
To examine the genetic association between colorectal cancer and schizophrenia, we analyzed five SNPs (rs6452526, rs2662238, rs963248, rs35268, rs2386275) covering ~205.7 kb in the region of XRCC4.
We observed that two of the five genetic polymorphisms showed statistically significant differences between 312 colorectal cancer subjects without schizophrenia and 270 schizophrenia subjects (rs6452536, p = 0.004, OR 0.61, 95% CI 0.44-0.86; rs35268, p = 0.028, OR 1.54, 95% CI 1.05-2.26). Moreover, the haplotype which combined all five markers was the most significant, giving a global p = 0.0005.
Our data firstly indicate that XRCC4 may be a potential protective gene towards schizophrenia, conferring reduced susceptibility to colorectal cancer in the Han Chinese population.