Morphology and plasticity of TStrC. a) TStrC, isolated from paediatric tumours, displayed an MSC-like, triangular morphology. b) - g) show differentiation assays toward the adipogenic (b, d, f) and toward the osteogenic (c, e, g) line. Fig. 4b+c: Osteosarcoma TStrC; Fig. 4d+e: Neuroblastoma TStrC; Fig. 4f+g: MSC (control). Osteogenic induction was successful in all 11 TStrC-preparations. However, adipogenic induction yielded poor or no differentiation of TStrC into adipocytes. Representative pictures for each source of stromal cells are shown.
Johann et al. BMC Cancer 2010 10:501 doi:10.1186/1471-2407-10-501