Unsupervised hierarchical clustering of high-grade serous carcinomas of the ovary with different BRCA1 status. Based on the expression profiles with 1603 filtered genes, there was no tendency for tumors to cluster based on BRCA1 status (BRCA1 loss through mutation, BRCA1 epigenetic loss through promoter hypermethylation, and no demonstrable BRCA1 loss). The length of the dendrogram arms is inversely proportional to the relatedness of gene expression between cases.
Pradhan et al. BMC Cancer 2010 10:493 doi:10.1186/1471-2407-10-493