Open Access Research article

Gross genomic alterations and gene expression profiles of high- grade serous carcinoma of the ovary with and without BRCA1 inactivation

Manohar Pradhan1, Björn Å Risberg12, Claes G Tropé34, Matt van de Rijn5, C Blake Gilks6* and Cheng-Han Lee6

Author Affiliations

1 Division of Pathology, Oslo University Hospital, Oslo, Norway

2 Institute for Medical Informatics, Oslo University Hospital, Oslo, Norway

3 Department of Gynecologic Oncology, Oslo University Hospital, Oslo, Norway

4 Faculty Division the Norwegian Radium Hospital, University of Oslo, Oslo, Norway

5 Department of Pathology, Stanford University Medical Center, Stanford, CA, USA

6 Department of Pathology and Laboratory Medicine, University of British Columbia and Vancouver General Hospital, Vancouver, British Columbia, Canada

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BMC Cancer 2010, 10:493  doi:10.1186/1471-2407-10-493

Published: 15 September 2010

Additional files

Additional file 1:

This is an excel file containing the full data for 1603 genes that met the filtering criteria.

Format: XLS Size: 1MB Download file

This file can be viewed with: Microsoft Excel Viewer

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Additional file 2:

This is an excel file containing the full data for 6843 genes that met a less stringent gene filtering criteria.

Format: XLS Size: 4.3MB Download file

This file can be viewed with: Microsoft Excel Viewer

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Additional file 3:

This is a table showing all the differentially expressed genes identified by significance analysis of microarray (SAM) between the different BRCA1-defined groups with a false-discovery rate (FDR) of < 20%.

Format: XLS Size: 32KB Download file

This file can be viewed with: Microsoft Excel Viewer

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Additional file 4:

Expression levels of BRCA1 and AREG for all cases. Expression level is depicted compared to the mean of all samples, with green indicating lower than mean expression level and red indicating higher than mean expression level. Black indicates expression at the mean for the entire group. Gray indicates missing data.

Format: TIFF Size: 108KB Download file

Open Data