DISC components are unchanged in VDAC1 knockdown cells. (A) Western blots showing expression of TRAIL receptor DR5, c-FLIP, and FADD, which are of comparable levels in sh-NT control and sh-VDAC1 cells, both before and after TRAIL treatment. (B) Flow cytometry showing cell surface expression of TRAIL receptors DR4 and DR5 in sh-NT and sh-VDAC1 cell lines. All cells show high levels of DR5 expression and relatively low levels of DR4.
Chacko et al. BMC Cancer 2010 10:380 doi:10.1186/1471-2407-10-380