Figure 1.

Schematic representation of (A) tamoxifen and (B) estradiol metabolism and the enzymes involved. 4OHtam, 4-hydroxytamoxifen; 4OHNDtam, 4-hydroxy-N-demethyltamoxifen; NDtam, N-dedimethyltamoxifen; NDDtam, N-dedimethyltamoxifen; tamNox, tamoxifen-N -oxide; CYP, cytochrome P450; SULT, sulfotransferase; UGT, Uridine 5'-diphospho-glucuronosyltransferase; E2, estradiol; E1, estrone; E1S, estrone sulphate; 4OHE2, 4-hydroxyE2; 2OHE2, 2-hydroxyE2; 4MeOE2, 4-methoxyE2; 2MeOE2, 2-methoxyE2; 4OHE1, 4-hydroxyE1; 2OHE1, 2-hydroxyE1; 4MeOE1, 4-methoxyE1; 2MeOE1, 2-methoxyE1; 16αOHE1, 16α-hydroxyE1; Catechol-O-methyl transferase, COMT. Bolded texts indicate tamoxifen and estrogen metabolizing enzymes investigated.

Gjerde et al. BMC Cancer 2010 10:313   doi:10.1186/1471-2407-10-313
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