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Open Access Highly Accessed Research article

Cruciferous vegetable intake is inversely associated with lung cancer risk among smokers: a case-control study

Li Tang*, Gary R Zirpoli, Vijayvel Jayaprakash, Mary E Reid, Susan E McCann, Chukwumere E Nwogu, Yuesheng Zhang, Christine B Ambrosone and Kirsten B Moysich

BMC Cancer 2010, 10:162  doi:10.1186/1471-2407-10-162

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GSTM1 and GSTT1 genes

Keith Grimaldi   (2010-07-12 15:17)  Eurogene http://eurogene.blogspot.com email

The study shows an impressive effect of cruciferous on lung cancer risk. I'm surprised though that the various work on GSTM1 and GSTT1 genes were not cited. In particular the Brennan 2005 article in Lancet is highly relevant, showing that the effect of cruciferous was limited to GSTT1 or GSTM1 null individuals (Brennan et al, Lancet, Volume 366, Issue 9496, Pages 1558 - 1560, 29 October 2005).

There is also a 2009 meta analysis reporting that higher cruciferous vegetable intake was consistently associated with lower lung cancer risk and was more marked in individuals with GSTM1 and GSTT1 null genotypes, emphasizing the potential importance of this gene-diet interaction. Lam et al, Cancer Epidemiol Biomarkers Prev 2009;18(1):184–95

Do you have plans to investigate the genetics?

Competing interests

None

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