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Li Tang*, Gary R Zirpoli, Vijayvel Jayaprakash, Mary E Reid, Susan E McCann, Chukwumere E Nwogu, Yuesheng Zhang, Christine B Ambrosone and Kirsten B Moysich
Corresponding author: Li Tang Li.Tang@RoswellPark.org
BMC Cancer 2010, 10:162 doi:10.1186/1471-2407-10-162
(2010-07-12 15:17) Eurogene http://eurogene.blogspot.com
The study shows an impressive effect of cruciferous on lung cancer risk. I'm surprised
though that the various work on GSTM1 and GSTT1 genes were not cited. In particular
the Brennan 2005 article in Lancet is highly relevant, showing that the effect of
cruciferous was limited to GSTT1 or GSTM1 null individuals (Brennan et al, Lancet, Volume 366, Issue 9496, Pages 1558 - 1560, 29 October 2005). There is also a 2009 meta analysis reporting that higher cruciferous vegetable intake
was consistently associated with lower lung cancer risk and was more marked in individuals
with GSTM1 and GSTT1 null genotypes, emphasizing the potential importance of this
gene-diet interaction. Lam et al, Cancer Epidemiol Biomarkers Prev 2009;18(1):184–95Do you have plans to investigate the genetics?
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