Ultrastructural overview by Transmission Electron Microscopy - Images of lungs with melanoma nodules. A: Lung cells in panoramic view, with nucleus (N), erythrocytes (E), pyknotic nucleus (PN), melanosomes (Me); B: Lung in a panoramic view with an evident tumor cell containing a big nucleus, melanosomes (Me) and many mitochondria; C: more details of a tumor cell, including the morphologic characteristics of intense metabolism, a big euchromatic nucleus, many mitochondria (Mi) and melanosomes. D: an alveolar macrophage with an euchromatic nucleus (N); many organelles, such as the endoplasmic reticulum and mitochondria, endocytic vacuoles, and internalized melanosomes (Me); and a surface covered with many cellular projections.
Guimarães et al. BMC Cancer 2010 10:113 doi:10.1186/1471-2407-10-113