Table 1

Percentage and intensity of staining for MCM2 and Ki-67 in normal bronchial mucosa and premalignant lesions
Type of
 Number of
 % Cells Positive
 % Cells Positive
 Mean
 Mean
Specimen
 Specimens
 for MCM2
 for Ki-67
 Intensity for
 Intensity


Mean (Range)
 Mean (Range)
 MCM2a
 for Ki-67a
Normal Mucosa
 7
 11b,e (5-20)
 3b,f (1-5)
 1.6i (1.0-2.0)
 1.6i (1.0-2.5)
Metaplasia
 21
 39c,e (7-90)
 14c,f (1-60)
 2.3i (1.0-3.0)
 2.3i (1.0-3.0)
Dysplasia
 7
 64d,e,g (40-100)
 34d,f (7-40)
 2.6i (2.0-3.0)
 2.8i (2.0-3.0)
CIS
 6
 39e,g (5-60)
 17f,h (3-60)
 2.4i (2.0-3.0)
 2.3i (1.0-3.0)
Combined data
 41
 39c(5-100)
 16c (1-60)
 2.2 (1.0 - 3.0)
 2.3 (1.0-3.0)

a The intensity of stain ranges from 0 (absent) to 3 (strong). b p-value < 0.016 for the paired difference t-test and Wilcoxon sign rank test. c p-value < 0.001 for the paired difference t-test and Wilcoxon sign rank test. d p-value < 0.034 for the paired difference t-test and <0.063 for the Wilcoxon sign-rank test. e p-value <0.010 for the ANOVA and Kruskal-Wallis tests of differences in MCM2 category means. f p-value <0.001 for the ANOVA and Kruskal-Wallis tests of differences in Ki-67 category means. g p-value <0.080 for the independent samples t-test between dysplasia and CIS within MCM2. h p-value <0.117 for the independent samples t-test between dysplasia and CIS within Ki67. i p-value <0.004 for the ANOVA and Kruskal-Wallis tests of differences in MCM2 and Ki-67 category means.

Tan et al. BMC Cancer 2001 1:6   doi:10.1186/1471-2407-1-6