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This article is part of the supplement: Proceedings of the First and Second European Workshops on Preterm Labour of the Special Non-Invasive Advances in Fetal and Neonatal Evaluation (SAFE) Network of Excellence

Open Access Proceedings

Protein kinase C and human uterine contractility

Isabelle Eude-Le Parco1, Emmanuelle Dallot23 and Michelle Breuiller-Fouché23*

Author Affiliations

1 Institut Jacques Monod, CNRS UMR7592, Université Paris 6 et 7, Paris, F-75006, France

2 INSERM U767, Paris, F-75006, France

3 Université René Descartes, Paris, F-75006, France

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BMC Pregnancy and Childbirth 2007, 7(Suppl 1):S11  doi:10.1186/1471-2393-7-S1-S11

Published: 1 June 2007

Abstract

Abnormalities in uterine contractility are thought to contribute to several clinical problems, including preterm labor. A better understanding of the mechanisms controlling uterine activity would make it possible to propose more appropriate and effective management practices than those currently in use. Recent advances point to a role of the protein kinase C (PRKC) family in the regulation of uterine smooth muscle contraction at the end of pregnancy. In this review, we highlight recent work that explores the involvement of individual PRKC isoforms in cellular process, with an emphasis on the properties of PRKCZ isoform.