Email updates

Keep up to date with the latest news and content from BMC Pregnancy and Childbirth and BioMed Central.

Open Access Research article

Recurrence of perinatal death in Northern Tanzania: a registry based cohort study

Michael J Mahande123*, Anne K Daltveit24, Blandina T Mmbaga123, Joseph Obure5, Gileard Masenga5, Rachel Manongi1 and Rolv T Lie24

Author Affiliations

1 Kilimanjaro Christian Medical University College, Moshi, Tanzania

2 Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway

3 Centre for International Health, University of Bergen, Bergen, Norway

4 Norwegian Institute of Public Health, Bergen, Norway

5 Department of Obstetrics and Gynaecology, Kilimanjaro Christian Medical Centre, Moshi, Tanzania

For all author emails, please log on.

BMC Pregnancy and Childbirth 2013, 13:166  doi:10.1186/1471-2393-13-166

Published: 29 August 2013

Abstract

Background

Perinatal mortality is known to be high in Sub-Saharan Africa. Some women may carry a particularly high risk which would be reflected in a high recurrence risk. We aim to estimate the recurrence risk of perinatal death using data from a hospital in Northern Tanzania.

Methods

We constructed a cohort study using data from the hospital based KCMC Medical Birth Registry. Women who delivered a singleton for the first time at the hospital between 2000 and 2008 were followed in the registry for subsequent deliveries up to 2010 and 3,909 women were identified with at least one more delivery within the follow-up period. Recurrence risk of perinatal death was estimated in multivariate models analysis while adjusting for confounders and accounting for correlation between births from the same mother.

Results

The recurrence risk of perinatal death for women who had lost a previous baby was 9.1%. This amounted to a relative risk of 3.2 (95% CI: 2.2 - 4.7) compared to the much lower risk of 2.8% for women who had had a surviving baby. Recurrence contributed 21.2% (31/146) of perinatal deaths in subsequent pregnancies. Preeclampsia, placental abruption, placenta previa, induced labor, preterm delivery and low birth weight in a previous delivery with a surviving baby were also associated with increased perinatal mortality in the next pregnancy.

Conclusions

Some women in Tanzanian who suffer a perinatal loss in one pregnancy are at a particularly high risk of also losing the baby of a subsequent pregnancy. Strategies of perinatal death prevention that target pregnant women who are particularly vulnerable or already have experienced a perinatal loss should be considered in future research.

Keywords:
Perinatal mortality; Perinatal death; Recurrence; Risk factors; Continuation rate