Table 2

GRADE Criteria for Quality of Evidence

Quality of Evidence

Study Design

Interpretation


High

Randomized Controlled Trials (RCTs)

Further research is very unlikely to change our confidence in the estimate of effect.

Moderate

Low-Quality Randomized Trials or High-Quality Observational Studies

Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.

Low

Observational Studies

Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.

Very Low

Any Other Evidence

Any estimate of effect is very uncertain.


Barros et al. BMC Pregnancy and Childbirth 2010 10(Suppl 1):S3   doi:10.1186/1471-2393-10-S1-S3

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