Email updates

Keep up to date with the latest news and content from BMC Medical Physics and BioMed Central.

Open Access Highly Accessed Research article

Assessment of diffuse Lewy body disease by 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography (FDG PET)

Siroos Mirzaei1*, Peter Knoll1, Horst Koehn1 and Thomas Bruecke2

Author Affiliations

1 Ludwig Boltzmann Institute of Nuclear Medicine, Wilhelminenspital, Austria

2 Department of Neurology, Wilhelminenspital, Vienna, Austria

For all author emails, please log on.

BMC Nuclear Medicine 2003, 3:1  doi:10.1186/1471-2385-3-1

Published: 20 February 2003

Abstract

Background

Lewy body disease is, after Alzheimer's disease, the second most common cause of senile degenerative dementia with progressive cognitive deterioration, fluctuation of cognitive and motoric functions and psychotic symptoms. It is characterized histologically by the occurrence of Lewy bodies in allocortical, neocortical and subcortical structures. The aim of this study was to measure the cortical glucose metabolism using FDG PET (2-[18F]fluoro-2-deoxy-D-glucose position emission tomography) compared to normal subjects.

Patients and Methods

Five patients (5 m, mean age 75 y) with clinically suspected diffuse Lewy body disease (DLB) were studied with FDG PET. PET studies of the head were performed with a Siemens ECAT-ART PET-scanner with attenuation correction using 137-Cs point sources.

Results

We found the same distribution pattern of diffuse glucose hypometabolism in the entire cortical region with relative sparing of the primary sensory-motor cortex in all the patients. The few cases reported in the literature so far describe findings similar to ours.

Conclusion

The pattern of diffuse glucose hypometabolism in the entire cortex including the occipital region seems to be a typical feature of DLB that is distinctive from dementia of Alzheimer's disease.

Keywords:
Dementia; FDG PET; Lewy body disease